More on renal salt wasting without cerebral disease: response to saline infusion. 76(9):934-8.īitew S, Imbriano L, Miyawaki N, Fishbane S, Maesaka JK. Maesaka JK, Imbriano LJ, Ali NM, Ilamathi E. Renal salt wasting without cerebral disease: diagnostic value of urate determinations in hyponatremia. Maesaka JK, Miyawaki N, Palaia T, Fishbane S, Durham JH. Syndrome of inappropriate antidiuresis and cerebral salt wasting syndrome: are they different and does it matter?. Renal salt-wasting syndrome in children with intracranial disorders. 65(5):925-35 discussion 935-6.īettinelli A, Longoni L, Tammaro F, Fare PB, Garzoni L, Bianchetti MG. Hyponatremia in neurosurgical patients: clinical guidelines development. A salt-wasting syndrome associated with cerebral disease. Failure to distinguish cerebral salt-wasting syndrome from SIADH in a patient with hyponatremia who has brain injury could lead to inappropriate therapy with fluid restriction. Attention to the volume status of the patient is important in making the distinction. However, distinguishing between the two disorders is important because treatment options differ. (See Pathophysiology, Etiology, and Presentation.) Management of cerebral salt-wasting syndrome centers on correction of intravascular volume depletion and hyponatremia, as well as on replacement of ongoing urinary sodium loss, usually with intravenous (IV) hypertonic saline solutions.ĭifferentiation of this disorder from the syndrome of inappropriate antidiuretic hormone secretion (SIADH), a common cause of hyponatremia, can be difficult because both can present with hyponatremia and concentrated urine with natriuresis. Complications of cerebral salt-wasting syndrome include symptomatic hyponatremia and dehydration.

As such, it may be more appropriately termed renal salt wasting. First described by Peters et al in 1950, cerebral salt-wasting syndrome is defined by the development of extracellular volume depletion due to a renal sodium transport abnormality in patients with intracranial disease and normal adrenal and thyroid function.

Wasted synonym